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Related Concept Videos

Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

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Cytomegalovirus Disease01:27

Cytomegalovirus Disease

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Related Experiment Videos

Multicentric reticulohistiocytosis: case report.

Eugene A de Zwart-Storm1, Ariënne M W van Marion, Simone L Gorter

  • 1Department of Dermatology, University Hospital Maastricht, The Netherlands. edz@sder.azm.nl

International Journal of Dermatology
|December 6, 2007
PubMed
Summary

Multicentric reticulohistiocytosis (MRH) is a rare adult disorder causing skin bumps and joint problems. Early diagnosis and interdisciplinary care are crucial due to potential malignancy links.

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Area of Science:

  • Dermatology
  • Rheumatology
  • Pathology

Background:

  • Multicentric reticulohistiocytosis (MRH) is a rare, non-Langerhans cell histiocytosis primarily affecting adults.
  • It is characterized by distinct clinical manifestations, including papulonodular cutaneous lesions and severe arthropathy.

Observation:

  • A 64-year-old woman presented with asymptomatic, slowly expanding red bumps on her hands and face over one year.
  • Histopathological examination revealed characteristic mononucleated and multinucleated giant cells with a 'ground glass' appearance.

Findings:

  • The clinical presentation and histopathological findings led to the diagnosis of multicentric reticulohistiocytosis (MRH).
  • This diagnosis highlights the importance of recognizing the specific cellular morphology in differentiating MRH from other histiocytic disorders.

Implications:

  • MRH requires an interdisciplinary approach for comprehensive patient management.
  • Given the association of MRH with underlying malignancies, prompt and thorough systemic evaluation is essential for affected individuals.