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Immunoglobulin-like Cell Adhesion Molecules

Immunoglobulin-like Cell Adhesion Molecules

Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...

Cell Adhesion Molecules - Types and Functions

Cell Adhesion Molecules - Types and Functions

Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
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Intracellular Signaling Affects Focal Adhesions

Intracellular Signaling Affects Focal Adhesions

Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...

Adherens Junctions

Adherens Junctions

Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types – adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
Adherens Junctions are Dynamic
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Selectins

Selectins

Cell adhesion is an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain, which...

Cadherins in Tissue Organization

Cadherins in Tissue Organization

The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
Cell Sorting During Development
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Related Experiment Video

Updated: Jul 10, 2026

Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane

Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane

Published on: February 8, 2020

[Intercellular adhesion molecule-1 expression in renal cell carcinoma].

D Brasanac, K Radotić-Smiljanić, G Basta-Jovanović

Srpski Arhiv Za Celokupno Lekarstvo

|July 1, 1995

Summary

Intercellular adhesion molecule-1 (ICAM-1) expression varied across renal cell carcinoma (RCC) subtypes. No direct correlation was found between ICAM-1 levels on tumor cells and RCC behavior or immune infiltration.

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Microfluidic Co-culture of Renal Healthy and Tumor Epithelium to Model Kidney Cancer Progression

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Last Updated: Jul 10, 2026

Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane

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Published on: February 8, 2020

Microfluidic Co-culture of Renal Healthy and Tumor Epithelium to Model Kidney Cancer Progression

Microfluidic Co-culture of Renal Healthy and Tumor Epithelium to Model Kidney Cancer Progression

Published on: January 31, 2025

Area of Science:

Oncology
Immunology
Pathology

Context:

Renal cell carcinoma (RCC) is a heterogeneous malignancy with varying prognoses.
Intercellular adhesion molecule-1 (ICAM-1) plays a role in immune cell adhesion and inflammation.
Understanding ICAM-1 expression in different RCC subtypes is crucial for elucidating tumor-immune interactions.

Purpose:

To investigate the expression patterns of ICAM-1 in various subtypes of renal cell carcinoma.
To determine any correlation between ICAM-1 expression and the degree of mononuclear cell infiltration in RCC.
To explore potential relationships between ICAM-1 expression and the clinical behavior of different RCC subtypes.

Summary:

ICAM-1 presence was analyzed in 27 RCC samples (clear cell, granular cell, chromophobe, sarcomatoid) using indirect immunoperoxidase staining.
Significant variations in ICAM-1 expression were noted in clear cell and granular cell RCC, independent of mononuclear cell infiltration.
Sarcomatoid RCC showed widespread ICAM-1 and intense infiltrate, while chromophobe RCC exhibited weak ICAM-1 expression with minimal infiltrate, despite a better prognosis.

Impact:

The study found no definitive link between tumor cell ICAM-1 expression and the behavior of diverse RCC types.
Possible explanations for varied ICAM-1 expression include differing histogenesis, non-specific upregulation due to ischemia-necrosis, or a negative impact on complement activity.
Further research is needed to clarify the precise role of ICAM-1 in RCC pathogenesis and its potential as a prognostic or therapeutic target.