Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Acute Pyelonephritis I: Introduction01:27

Acute Pyelonephritis I: Introduction

Pyelonephritis is a bacterial infection that primarily affects the renal parenchyma and collecting system, including the renal pelvis, tubules, and interstitial tissue of one or both kidneys. It can be classified as either acute—a sudden, severe infection—or chronic, which refers to long-term or recurrent kidney infections.The primary cause of acute pyelonephritis (APN) is bacterial infection, with Escherichia coli accounting for approximately 70-80% of cases. Other bacteria, such as Proteus,...
Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Analysis of hip joint loading during walking with different shoe types using instrumented total hip prostheses.

Scientific reports·2021
Same author

Photocatalytic degradation of methylene blue under natural sunlight using iron titanate nanoparticles prepared by a modified sol-gel method.

Royal Society open science·2020
Same author

Characterizing plasma with emission tomography-Feasibility study on synthetic and experimental data.

The Review of scientific instruments·2020
Same author

Anastomosing hemangioma of the kidney: radiologic and pathologic distinctions of a kidney cancer mimic.

Current oncology (Toronto, Ont.)·2018
Same author

Vascular anatomy of the thenar eminence: its relevance to a pedicled or free thenar flap.

Folia morphologica·2016
Same author

Prevalence and diagnostic significance of specific IgA and anti-heat shock protein 60 Chlamydia trachomatis antibodies in subfertile women.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology·2014

Related Experiment Video

Updated: Jul 10, 2026

Primed Mycobacterial Uveitis (PMU) as a Model for Post-Infectious Uveitis
10:33

Primed Mycobacterial Uveitis (PMU) as a Model for Post-Infectious Uveitis

Published on: December 17, 2021

[Acute tubulointerstitial nephritis with uveitis].

V Nikolić, R Bogdanović, M Ognjanović

    Srpski Arhiv Za Celokupno Lekarstvo
    |January 1, 1995
    PubMed
    Summary

    Tubulointerstitial nephritis and uveitis (TINU) syndrome in adolescents presents with nonspecific symptoms and kidney dysfunction. This condition typically shows a benign course with full renal recovery, often managed with steroids.

    Area of Science:

    • Nephrology
    • Ophthalmology
    • Pediatrics

    Context:

    • Tubulointerstitial nephritis and uveitis (TINU) syndrome is a rare condition affecting adolescents.
    • Early symptoms can be nonspecific, including anorexia, weight loss, fever, and malaise.
    • Diagnosis is supported by urinalysis showing proteinuria and sterile pyuria, alongside evidence of tubular dysfunction and reduced glomerular filtration rate (GFR).

    Purpose:

    • To describe the clinical features and natural course of TINU syndrome in a cohort of five adolescent patients.
    • To highlight the diagnostic challenges and treatment outcomes for TINU syndrome in a pediatric population.

    Summary:

    • The study presents five adolescent cases of TINU syndrome, characterized by initial nonspecific symptoms followed by renal involvement and later-onset anterior uveitis.

    More Related Videos

    Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model
    07:40

    Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model

    Published on: January 12, 2022

    Induction of Ocular Surface Inflammation and Collection of Involved Tissues
    06:38

    Induction of Ocular Surface Inflammation and Collection of Involved Tissues

    Published on: August 4, 2022

    Related Experiment Videos

    Last Updated: Jul 10, 2026

    Primed Mycobacterial Uveitis (PMU) as a Model for Post-Infectious Uveitis
    10:33

    Primed Mycobacterial Uveitis (PMU) as a Model for Post-Infectious Uveitis

    Published on: December 17, 2021

    Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model
    07:40

    Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model

    Published on: January 12, 2022

    Induction of Ocular Surface Inflammation and Collection of Involved Tissues
    06:38

    Induction of Ocular Surface Inflammation and Collection of Involved Tissues

    Published on: August 4, 2022

  • Laboratory findings included elevated ESR, hyperproteinemia, hypergammaglobulinemia, proteinuria, sterile pyuria, tubular dysfunction, and decreased GFR.
  • Renal biopsy in two patients confirmed acute interstitial nephritis. Anterior uveitis responded well to topical steroids, and renal function recovered significantly in most patients within months.

    • Impact:

    • This study underscores the importance of recognizing TINU syndrome in adolescents presenting with acute kidney injury and uveitis.
    • The findings suggest that TINU syndrome in this age group often follows a benign clinical course with favorable renal outcomes.
    • Prompt diagnosis and management, including topical steroid treatment for uveitis, are crucial for achieving complete recovery.