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Published on: December 13, 2014
The relationship between avoidant personality disorder and social phobia: a population-based twin study
Ted Reichborn-Kjennerud1, Nikolai Czajkowski, Svenn Torgersen
1Norwegian Institute of Public Health, Box 4404, Nydalen N-0403, Oslo, Norway. ted.reichborn-kjennerud@fhi.no
Social phobia and avoidant personality disorder share common genetic factors, but unique environmental influences determine which disorder develops. This suggests a shared genetic vulnerability in women.
Area of Science:
- Psychiatric Genetics
- Clinical Psychology
- Twin Studies
Background:
- Social phobia (SP) and avoidant personality disorder (APD) are frequently comorbid, suggesting shared underlying factors.
- Understanding the etiology of comorbidity is crucial for developing effective prevention and treatment strategies.
Purpose of the Study:
- To investigate the genetic and environmental sources of comorbidity between SP and dimensional APD.
- To estimate the relative contributions of shared and unique genetic and environmental factors to both disorders.
Main Methods:
- A population-based sample of 1,427 female twin pairs from the Norwegian Institute of Public Health Twin Panel was assessed.
- Participants were interviewed using the Structured Interview for DSM-IV Personality and the Composite International Diagnostic Interview.
- Bivariate Cholesky models were employed using the Mx statistical program to analyze genetic and environmental influences.
Main Results:
- The best-fitting model indicated that both additive genetic factors and unique environmental factors influenced SP and APD.
- The same genetic factors were found to influence both avoidant personality disorder and social phobia.
- Environmental factors contributing to each disorder were uncorrelated, suggesting they are unique to each condition.
Conclusions:
- A common genetic vulnerability likely underlies avoidant personality disorder and social phobia in women.
- Environmental risk factors unique to each disorder appear to determine the specific diagnosis in genetically predisposed individuals.
- Findings support the hypothesis of psychobiological dimensions spanning across Axis I and Axis II disorders.
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