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New semiquantitative dipstick test for microalbuminuria
H J Bangstad1, K Try, K Dahl-Jørgensen
1Aker Diabetes Research Center, Department of Pediatrics, Medicine and Clinical Chemistry, Aker University Hospital, Oslo, Norway.
Diabetes Care
|November 1, 1991
Summary
The Micral-Test offers a reliable method for screening microalbuminuria in diabetic patients. This dipstick test accurately identifies elevated urinary albumin concentration, aiding in early detection and monitoring.
Area of Science:
- Nephrology
- Diabetology
- Clinical Chemistry
Background:
- Microalbuminuria is an early indicator of diabetic nephropathy.
- Accurate and accessible screening methods are crucial for early intervention.
Purpose of the Study:
- To evaluate the performance of the Micral-Test, a new semiquantitative dipstick test.
- To compare the Micral-Test against a quantitative immunoturbidimetric method for microalbuminuria detection.
Main Methods:
- A correlation study involving 186 diabetic patients at a university hospital outpatient clinic.
- Analysis of overnight urine samples using both the Micral-Test and an immunoturbidimetric assay.
Main Results:
- A strong correlation coefficient of 0.82 was observed between the Micral-Test and the reference method.
- The Micral-Test demonstrated a sensitivity of 92.3% and specificity of 82.1% for detecting elevated urinary albumin concentration (>20 mg/L).
- Overall, 84.9% of diabetic subjects were correctly classified.
Conclusions:
- The Micral-Test is a valuable tool for in-clinic screening of elevated urinary albumin.
- It assists in monitoring the progression of microalbuminuria in diabetic patients.