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Updated: Jul 10, 2026
13:29
Rapid Identification of Gram Negative Bacteria from Blood Culture Broth Using MALDI-TOF Mass Spectrometry
Published on: May 28, 2014
Management of Gram-positive bacteraemia
Ilker Uçkay1, Stephan Harbarth, Didier Pittet
1Division of Infectious Diseases, University of Geneva Hospitals, Geneva, Switzerland.
Current Opinion in Infectious Diseases
|November 3, 2007
Summary
Recent findings on Gram-positive bacteraemia show no major treatment advances. However, rising vancomycin resistance in Staphylococcus aureus is a concern, while daptomycin shows promise for infections and endocarditis.
Area of Science:
- Infectious Diseases
- Microbiology
- Internal Medicine
Background:
- Gram-positive bacteraemia presents significant morbidity and mortality.
- A review of recent literature is crucial for understanding emerging trends.
Purpose of the Study:
- To review new findings on Gram-positive bacteraemia from July 2006 to June 2007.
- To identify advancements in epidemiology, prevention, and treatment.
Main Methods:
- Systematic review of published literature.
- Inclusion of articles focusing exclusively on Gram-positive bacteraemia.
- Analysis of 98 reviewed articles, with 66 incorporated into the final review.
Main Results:
- 21 articles focused on epidemiology and prevention.
- 32 articles addressed Staphylococcus aureus bacteraemia.
- 11 articles covered other Gram-positive pathogens, daptomycin, endocarditis, diagnostics, and antibiotic lock techniques.
Conclusions:
- No fundamental treatment breakthroughs were identified.
- Increasing vancomycin minimum inhibitory concentrations in Staphylococcus aureus pose a potential threat.
- Daptomycin demonstrated in-vivo efficacy; antibiotic lock techniques and rapid molecular diagnostics show promise. Further validation is needed.
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