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Updated: Jul 10, 2026

Bronchoalveolar Lavage (BAL) for Research; Obtaining Adequate Sample Yield
Published on: March 24, 2014
Technical aspects of bronchoalveolar lavage: recommendations for a standard procedure
1Division of Pulmonary and Critical Care Medicine, University of Cincinnati Medical Center, Cincinnati, Ohio 45267-0565, USA. bob.baughman@uc.edu
Abstract:
Bronchoalveolar lavage (BAL) has been used widely in the diagnosis of infection. More than 30 years after its description, its use in the clinical management of interstitial lung disease remains controversial. One limitation has been the variations in how the specimen is obtained and handled. Several groups have developed recommendations for obtaining and handling BAL specimens. This article summarizes these recommendations and discusses the variable effects they have on BAL results. The final recommendations provide a standard methodology that can be used by the largest number of pulmonologists.
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