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Related Concept Videos

What is Cancer?02:12

What is Cancer?

Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...
What is Cancer?02:12

What is Cancer?

Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...
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Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Skin Cancer

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Related Experiment Video

Updated: Jul 10, 2026

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
09:25

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

Sarcoma.

Keith M Skubitz1, David R D'Adamo

  • 1Department of Medicine, University of Minnesota Medical School and Masonic Cancer Center, Minneapolis, USA. skubi001@umn.edu

Mayo Clinic Proceedings
|November 3, 2007
PubMed
Summary

This review covers diverse soft tissue and bone sarcomas, emphasizing that tumor grade, size, and location are key prognostic factors. Expert evaluation and tailored treatment are crucial for managing these rare cancers.

Area of Science:

  • Oncology
  • Pathology
  • Surgical Oncology

Background:

  • Sarcomas are a diverse group of rare mesenchymal neoplasms.
  • They are broadly classified into soft tissue sarcomas and primary bone sarcomas.
  • Each category requires distinct staging and treatment strategies.

Purpose of the Study:

  • To provide a comprehensive overview of various soft tissue and primary bone sarcoma types.
  • To highlight critical prognostic variables in sarcoma management.
  • To outline the recommended diagnostic and therapeutic approach for sarcoma patients.

Main Methods:

  • Review of current literature and established classifications of sarcomas.
  • Discussion of specific subtypes including malignant fibrous histiocytoma, liposarcoma, osteosarcoma, and Ewing sarcoma.

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The In ovo CAM-assay as a Xenograft Model for Sarcoma
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The In ovo CAM-assay as a Xenograft Model for Sarcoma

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  • Emphasis on the importance of initial biopsy and multidisciplinary team evaluation.

    • Main Results:

    • Identified grade, size, and location as the three most significant prognostic indicators for sarcomas.
    • Detailed the diagnostic pathway starting with an adequate biopsy.
    • Stressed the need for specialized oncologic teams due to sarcoma heterogeneity.

    Conclusions:

    • Sarcoma management necessitates accurate diagnosis, consideration of prognostic factors, and specialized care.
    • Treatment plans must be individualized based on the specific sarcoma subtype.
    • Adherence to established guidelines, such as those from the National Comprehensive Cancer Network, is recommended.