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Related Experiment Videos

Resistant coagulase negative staphylococci from clinical samples.

M M Goel1, A V Singh, S K Mathur

  • 1Postgraduate Department of Pathology & Microbiology, K.G. Medical College, Lucknow.

The Indian Journal of Medical Research
|November 1, 1991
PubMed
Summary
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Coagulase-negative staphylococci show high resistance to common antibiotics like cotrimoxazole and tetracycline. Vancomycin and cefotaxime remain highly effective against these challenging clinical pathogens.

Area of Science:

  • Microbiology
  • Clinical Medicine
  • Pharmacology

Background:

  • Coagulase-negative staphylococci (CoNS) are significant opportunistic pathogens.
  • Increasing antibiotic resistance in CoNS complicates treatment of serious infections.

Purpose of the Study:

  • To determine the antibiotic susceptibility profiles of 96 CoNS strains.
  • To identify effective antibiotics for treating CoNS infections.

Main Methods:

  • Antibiotic susceptibility testing using the Stokes method.
  • Evaluated 96 CoNS strains against 17 different antibiotics.

Main Results:

  • High sensitivity (>90%) observed for vancomycin, cefotaxime, ciprofloxacin, clavulanate potentiated amoxycillin, cloxacillin, and clindamycin.

Related Experiment Videos

  • Highest resistance rates were against cotrimoxazole (77.08%) and tetracycline (64.59%).
  • Clavulanate potentiated amoxycillin demonstrated activity against penicillin-resistant strains.

    • Conclusions:

    • Antibiotic resistance typing is crucial for CoNS species.
    • Effective empiric therapy selection is challenging due to resistance patterns.
    • Vancomycin and cefotaxime are reliable options for CoNS infections.