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Related Experiment Video

Updated: Jul 10, 2026

Using a Cell-Tracer Injection to Investigate the Origin of Neointima-Forming Cells in a Rat Saccular Side Wall Model

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Perianeurysm edema with second-generation bioactive coils.

Franklin A Marden¹, Christopher M Putman

¹Division of Interventional Neuroradiology, Department of Radiology, Inova Fairfax Hospital, Falls Church, VA 22042, USA. franklin.marden@inova.com

Surgical Neurology

|November 3, 2007

Summary

Perianeurysm edema, a rare complication of intracranial aneurysms, can occur after embolization with bioactive coils. This case highlights the need for vigilance and potential earlier surveillance angiography.

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Area of Science:

Neurology
Interventional Neuroradiology
Vascular Neurology

Background:

Perianeurysm edema is a rare complication associated with intracranial aneurysms, typically observed in giant aneurysms that undergo thrombosis.
This condition involves swelling around the aneurysm, often linked to inflammatory processes.

Observation:

This report details the first instance of significant perianeurysm edema in an unruptured, nongiant saccular aneurysm following embolization with Matrix2 coils.
Follow-up angiography revealed a protruding coil tail near the area of maximal edema, suggesting a potential cause.

Findings:

The study suggests that perianeurysm edema may arise from aneurysm wall compromise and subsequent inflammatory reactions to exposed bioactive coil components.
The protruding coil tail is hypothesized to be a trigger for the inflammatory response and edema formation.

Implications:

Clinicians should recognize perianeurysm edema as a potential complication after aneurysm embolization, even in non-giant aneurysms.
Consideration of earlier surveillance angiography is advised to monitor for coil mass displacement and potential aneurysm recurrence.