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Induction of Atherosclerotic Plaques Through Activation of Mineralocorticoid Receptors in Apolipoprotein E-deficient Mice
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Classic versus non-classic receptors for nongenomic mineralocorticoid responses: emerging evidence

Ralf M Lösel1, Martin Wehling

  • 1Clinical Pharmacology Mannheim, University of Heidelberg, Mannheim, Germany.

Frontiers in Neuroendocrinology
|November 3, 2007
PubMed

Insights

Mineralocorticoids in the brain trigger genomic and nongenomic responses. Research is exploring the receptors mediating these nongenomic effects, with classic receptors showing new properties and novel membrane receptors emerging.

Area of Science:

  • Neuroendocrinology
  • Molecular Biology
  • Cellular Signaling

Background:

  • Mineralocorticoids are produced both in the adrenal glands and centrally in the nervous system.
  • These hormones elicit both genomic and nongenomic cellular responses.
  • The central nervous system (CNS) functions of mineralocorticoids are increasingly recognized.

Purpose of the Study:

  • To review known functions of mineralocorticoids in the CNS.
  • To discuss nongenomic mineralocorticoid responses in various tissues.
  • To address the ongoing scientific debate surrounding the identity of receptors mediating nongenomic, transcription-independent steroid actions.

Main Methods:

  • Literature review of existing studies on mineralocorticoid actions.
  • Analysis of evidence supporting classic nuclear receptors versus novel membrane receptors for nongenomic effects.
  • Comparison of research tools available for studying classic versus alternative steroid receptors.

Main Results:

  • Classic nuclear receptors show evidence for mediating nongenomic steroid effects in some contexts.
  • Evidence for classic receptors is lacking in other instances, fueling interest in alternative receptors.
  • Recent discoveries highlight unexpected properties of classic receptors, shifting focus away from novel membrane receptors.

Conclusions:

  • The identity of receptors mediating nongenomic steroid responses remains a significant area of scientific inquiry.
  • Advancements in understanding classic receptor properties are influencing the search for novel receptors.
  • Clarifying receptor involvement is crucial for the medical translation of targeted steroid therapies.

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