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The effect of single-dose tramadol on oxycodone clearance
Steven C Curry1, David J Watts, Kenneth D Katz
1Department of Medical Toxicology, Banner Good Samaritan Medical Center, Phoenix, Arizona, USA.
The Journal of Emergency Medicine
|November 3, 2007
Summary
This study found that a single dose of tramadol did not significantly affect how the body processes oxycodone. Researchers concluded that tramadol does not impair oxycodone clearance in patients.
Area of Science:
- Pharmacology
- Clinical Pharmacology
- Drug Metabolism
Background:
- Increased co-prescription of tramadol and oxycodone observed.
- Both opioids are metabolized by CYP2D6 and CYP3A4 enzymes.
- Potential for metabolic competition between tramadol and oxycodone.
Purpose of the Study:
- To investigate if single-dose tramadol impairs oxycodone clearance.
- To assess the interaction between tramadol and oxycodone metabolism.
Main Methods:
- Randomized controlled trial with 10 healthy volunteers.
- Each subject served as their own control (crossover design).
- Measured plasma oxycodone and oxymorphone concentrations over 8 hours after oral oxycodone administration, with or without preceding tramadol.
Main Results:
- No statistically significant difference in oxycodone clearance (CL/f) between the control and tramadol arms.
- No significant differences observed in peak oxycodone concentrations (Cmax) or time to peak concentration (Tmax).
Conclusions:
- Single-dose tramadol did not demonstrate impairment of oxycodone clearance in this study.
- Further research may be needed to fully understand the clinical implications of tramadol-oxycodone co-administration.
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