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Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
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Outcomes of elderly heart failure recipients of ICD and CRT

Wolfram Grimm1

  • 1Department of Internal Medicine and Cardiology, University Medical Center Giessen and Marburg, Germany. grimmw@med.uni-marburg.de

International Journal of Cardiology
|November 3, 2007
PubMed

Insights

Implantable cardioverter defibrillators (ICDs) and cardiac resynchronization therapy (CRT) benefit heart failure patients. This review examines their use in elderly individuals, synthesizing evidence from trials and cohort studies.

Area of Science:

  • Cardiology
  • Geriatric Medicine
  • Medical Devices

Background:

  • Implantable cardioverter defibrillator (ICD) and cardiac resynchronization therapy (CRT) are established treatments for heart failure.
  • Current evidence primarily comes from trials with younger populations (mean age 60-65).
  • Limited data exists specifically for elderly heart failure patients.

Purpose of the Study:

  • To review the efficacy and safety of ICDs and CRT in elderly heart failure patients.
  • To synthesize evidence from subgroup analyses and cohort studies.
  • To inform clinical practice regarding device therapy in older adults.

Main Methods:

  • Review of subgroup analyses from prospective randomized ICD and CRT intervention trials.
  • Analysis of published cohort studies focusing on elderly heart failure populations.
  • Synthesis of available scientific evidence.

Main Results:

  • Evidence suggests ICD and CRT can be effective in selected elderly heart failure patients.
  • Subgroup analyses provide insights into device therapy in older adults.
  • Cohort studies offer real-world data on outcomes.

Conclusions:

  • ICD and CRT may offer benefits for elderly heart failure patients, but require careful patient selection.
  • Further research specifically targeting elderly populations is warranted.
  • This review consolidizes current evidence for clinical decision-making.

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