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Related Concept Videos

Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immune Surveillance by NK Cells and Phagocytes01:25

Immune Surveillance by NK Cells and Phagocytes

Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists01:28

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists

Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy.  SP binds and activates these...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

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[Allergic states in workers of hemp industry in Novi Becej, Leskovac and Vranjska Banja].

Glasnik (Srpska akademija nauka)·2014
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In vitro increased natural killer cell activity of metastatic melanoma patients with interferon-α alone as opposed to its combination with 13-cis retinoic acid is associated with modulation of NKG2D and CD161 activating receptor expression.

Journal of B.U.ON. : official journal of the Balkan Union of Oncology·2013
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Association of decreased NK cell activity and IFNγ expression with pSTAT dysregulation in breast cancer patients.

Journal of B.U.ON. : official journal of the Balkan Union of Oncology·2011
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Novel aspects of in vitro IL-2 or IFN-α enhanced NK cytotoxicity of healthy individuals based on NKG2D and CD161 NK cell receptor induction.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2010
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[Immunoglobulins G, A, M and circulatory immune complexes in patients with laryngeal carcinoma].

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Related Experiment Video

Updated: Jul 10, 2026

Advances in Human Induced Pluripotent Stem Cell-Derived Chimeric Antigen Receptor-Expressing Natural Killer Cells
11:08

Advances in Human Induced Pluripotent Stem Cell-Derived Chimeric Antigen Receptor-Expressing Natural Killer Cells

Published on: February 14, 2025

[NK cells in malignant diseases].

G Konjević, I Spuzić

    Srpski Arhiv Za Celokupno Lekarstvo
    |May 1, 1994
    PubMed
    Summary

    Natural killer (NK) cells are crucial for fighting cancer. Their activity diminishes as malignancies advance, but understanding their subpopulations and activation offers therapeutic potential.

    Area of Science:

    • Immunology
    • Oncology

    Context:

    • Natural killer (NK) cells play a vital role in the immune system's defense against malignancy.
    • Human studies reveal impaired NK cell activity in various cancers, worsening with disease progression.

    Purpose:

    • To detail the role of NK cells in cancer defense.
    • To discuss causes of diminished NK cell activity and the influence of sera.
    • To explore NK cell subpopulations and their activation for immunotherapy.

    Summary:

    • NK cell activity is crucial for cancer immunity and declines with advancing malignancy.
    • Factors contributing to reduced NK cell function, including serum effects, are examined.
    • Characteristics of NK cell subsets and their potential for in vivo and in vitro activation in adoptive immunotherapy are presented.

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    Flow Cytometry-based Assay for the Monitoring of NK Cell Functions

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    Advances in Human Induced Pluripotent Stem Cell-Derived Chimeric Antigen Receptor-Expressing Natural Killer Cells
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    Published on: February 14, 2025

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    Published on: January 24, 2020

    Flow Cytometry-based Assay for the Monitoring of NK Cell Functions
    08:17

    Flow Cytometry-based Assay for the Monitoring of NK Cell Functions

    Published on: October 30, 2016

    Impact:

    • Provides insights into NK cell dysfunction in cancer.
    • Highlights the potential of modulating NK cell activity for cancer treatment strategies.
    • Informs the development of novel immunotherapeutic approaches targeting NK cells.