Related Experiment Video
Updated: Jul 10, 2026
Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
Published on: October 14, 2016
Adult-type soft tissue sarcomas in paediatric age: a nomogram-based prognostic comparison with adult sarcoma
Andrea Ferrari1, Rosalba Miceli, Michela Casanova
1Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milano, Italy. andrea.ferrari@institutotumori.mi.it
Introduction:
The study compares the outcome of paediatric patients with adult-type soft tissue sarcomas with that reported for adults, taking into account the effect of established prognostic factors.
Methods:
The actual mortality of our series was compared with that predicted by the nomogram developed for adults at the Memorial Sloan Kettering Cancer Center. From a previously-published series of 182 patients <18 years, 112 cases fulfilling the criteria for the nomogram application were selected.
Results:
Actual 10-year mortality for the series was 29%, compared with a 16% predicted mortality. The effect of individual covariates was qualitatively consistent with that of adults, but the unfavourable prognostic effect of tumour size was stronger in paediatric cases.
Conclusion:
The variables known to have a prognostic role in adults are relevant also in children. The worse outcome observed in our series might be explained by the stronger adverse effect of tumour size in young patients.
Related Concept Videos
01:21Cancer Survival Analysis
01:23Dosage Regimen Designs: Nomograms and Tabulations
01:18Distinctive Features of Adult Stem Cells vs Cancer Stem Cells
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...