Estimating the success of an in vitro fertilization programme using multiple imputation
N Soullier1, J Bouyer, J L Pouly
1INSERM, U822, 82 rue du Général Leclerc, F-94276 Le Kremlin-Bicêtre Cedex, France. soullier@vjf.inserm.fr
Human Reproduction (Oxford, England)
|November 6, 2007
Summary
This study estimates cumulative live birth rates in in vitro fertilization (IVF) using multiple imputation. The method accounts for treatment interruptions, showing a 46% success rate after four IVF cycles.
Area of Science:
- Reproductive medicine
- Biostatistics
Background:
- In vitro fertilization (IVF) outcomes are typically evaluated per oocyte retrieval.
- Previous evaluations did not fully account for treatment interruptions.
Purpose of the Study:
- To estimate the cumulative live birth rate after four IVF aspirations.
- To utilize multiple imputation to account for treatment interruptions.
Main Methods:
- Analysis of data from 3037 couples undergoing IVF treatment (1998-2002).
- Application of multiple imputation to estimate outcomes for couples discontinuing treatment.
- Computation of the global success rate after four aspirations.
Main Results:
- At the first aspiration, 21% of couples achieved live birth; 24% discontinued treatment.
- Multiple imputation estimated cumulative live birth rates of 35% (2nd aspiration) and 41% (3rd aspiration).
- The estimated cumulative success rate after four aspirations was 46% (95% CI: 44-48%).
Conclusions:
- Multiple imputation offers a promising approach for evaluating cumulative IVF success rates.
- This method provides new insights into IVF evaluation.
- Further studies are recommended to validate the use of multiple imputation in IVF research.
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The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
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