Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
Ribosomal RNA Synthesis02:53

Ribosomal RNA Synthesis

Ribosome synthesis is a highly complex and coordinated process involving more than 200 assembly factors. The synthesis and processing of ribosomal components occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells.
Ribosome biogenesis begins with the synthesis of 5S and 45S pre-rRNAs by distinct RNA polymerases. The primary transcripts are extensively processed and modified before they are bound and folded by ribosomal proteins and assembly factors,...
Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
Experimental RNAi02:15

Experimental RNAi

RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A human-specific microRNA controls the timing of excitatory synaptogenesis.

Nature communications·2026
Same author

Transcranial pulse stimulation modulates spectral signatures of Alzheimer's disease in the 3×Tg-AD mouse model.

Alzheimer's research & therapy·2026
Same author

The Unexplored Role of Noncoding Regulatory RNAs in Engram Dynamics.

The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry·2026
Same author

Accessory microRNA byproducts expand RNA interference via microprocessor-mediated cleavage activation.

Science advances·2026
Same author

Peripheral MicroRNA Expression Patterns as Biomarkers for Adolescent Depression.

Biological psychiatry global open science·2025
Same author

MicroRNA-138-5p suppresses excitatory synaptic strength at the cerebellar input layer.

The Journal of physiology·2025

Related Experiment Video

Updated: Jul 10, 2026

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
09:36

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

Noncoding RNAs in the brain.

John S Satterlee1, Scott Barbee, Peng Jin

  • 1Division of Basic Neuroscience and Behavioral Research, National Institute on Drug Abuse, Bethesda, Maryland 20892, USA. satterleej@nida.nih.gov

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|November 6, 2007
PubMed
Summary
This summary is machine-generated.

Thousands of noncoding RNAs (ncRNAs) in cells have unknown neuronal functions. Research suggests ncRNAs play roles in brain development and are implicated in neurological diseases.

More Related Videos

Enhanced Northern Blot Detection of Small RNA Species in Drosophila Melanogaster
09:39

Enhanced Northern Blot Detection of Small RNA Species in Drosophila Melanogaster

Published on: August 21, 2014

Related Experiment Videos

Last Updated: Jul 10, 2026

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
09:36

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

Enhanced Northern Blot Detection of Small RNA Species in Drosophila Melanogaster
09:39

Enhanced Northern Blot Detection of Small RNA Species in Drosophila Melanogaster

Published on: August 21, 2014

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • Cells produce numerous noncoding RNAs (ncRNAs) without known protein-coding functions.
  • The specific roles of ncRNAs in neuronal processes are largely uncharacterized.
  • Existing research links certain ncRNAs to dendritic spine development, neuronal differentiation, and synaptic functions.

Purpose of the Study:

  • To explore the largely unknown functions of noncoding RNAs (ncRNAs) in the nervous system.
  • To investigate the potential involvement of ncRNAs in neurodevelopmental and neuropsychiatric disorders.

Main Methods:

  • Literature review and synthesis of current research on ncRNAs in neuroscience.
  • Analysis of existing data linking ncRNAs to specific cellular and disease processes.

Main Results:

  • Noncoding RNAs (ncRNAs) are increasingly recognized for their regulatory roles in neurons.
  • Specific ncRNAs have been demonstrated to influence key neuronal functions like synapse formation and protein synthesis.
  • ncRNAs are implicated in the pathophysiology of disorders such as Tourette's syndrome and Fragile X syndrome.

Conclusions:

  • Noncoding RNAs (ncRNAs) represent a significant, understudied class of molecules in neuronal function.
  • Further research is expected to uncover more ncRNA functions and their roles in various brain disorders.