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In silico and in vitro pharmacogenetic analysis in mice

Yingying Guo1, Peng Lu, Erin Farrell

  • 1Department of Genetics and Genomics, Roche Palo Alto, Palo Alto, CA 94304, USA.

Proceedings of the National Academy of Sciences of the United States of America
|November 6, 2007
PubMed
Summary

This study introduces a novel model system combining in vitro hepatic drug metabolism and in silico genetic analysis to rapidly assess interindividual differences in drug metabolism, using testosterone and irinotecan as test cases.

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