Related Experiment Video
Updated: Jul 10, 2026

Optimized Minimally Invasive Transscleral Subretinal Injection Technique in Mouse
Published on: July 25, 2025
[Topical versus peribulbar anesthesia in nonpenetrating deep sclerectomy]
R A Paletta Guedes1, V Paletta Guedes, A Pereira Da Silva
1Centre Ophtalmologique Paletta Guedes, Juiz de Fora-MG, Brésil. palettaguedes@yahoo.com
Topical anesthesia with propofol sedation offers superior pain relief immediately after nonpenetrating deep sclerectomy compared to peribulbar anesthesia. Patient comfort levels were similar between the two anesthesia methods 24 hours post-surgery.
Area of Science:
- Ophthalmology
- Anesthesiology
- Surgical Innovation
Context:
- Ophthalmic surgery has advanced significantly, with topical anesthesia becoming standard for cataract procedures due to improved patient recovery.
- Previous studies suggest topical anesthesia can be effective for trabeculectomy, indicating its potential for other glaucoma surgeries.
- Nonpenetrating deep sclerectomy is a surgical option for glaucoma management, necessitating effective anesthesia for patient comfort and surgical success.
Purpose:
- To compare patient pain and comfort levels following nonpenetrating deep sclerectomy under two different anesthesia techniques: topical anesthesia with sedation versus peribulbar anesthesia.
- To evaluate pain perception at two time points: 15 minutes and 24 hours after the surgical procedure.
Summary:
- A randomized prospective study involving 69 patients undergoing nonpenetrating deep sclerectomy compared topical anesthesia (proximetacaine 0.5% with propofol sedation) to peribulbar anesthesia (lidocaine 2% with bupivacaine 0.75%).
- Patients receiving topical anesthesia reported significantly less pain 15 minutes post-surgery (mean VAS 0.11 vs. 0.82, p=0.014).
- No significant difference in pain was observed between the groups at the 24-hour follow-up (mean VAS 2.83 vs. 2.45, p=0.125).
Impact:
- Topical anesthesia combined with propofol sedation provides a valuable and effective alternative for nonpenetrating deep sclerectomy, potentially enhancing immediate postoperative patient experience.
- This approach may offer comparable or improved comfort levels to traditional peribulbar anesthesia, supporting its wider adoption in ophthalmic procedures.
- The findings contribute to optimizing anesthetic protocols in glaucoma surgery, focusing on patient-centered outcomes like pain management and comfort.
Related Concept Videos
Local Anesthetics: Common Agents and Their Applications
Cocaine is an ester of benzoic acid and methylecgogine. It is used to anesthetize and vasoconstrict locally. Currently, it is used primarily for topical applications. It is beneficial for surgeries on the upper respiratory tract, providing anesthesia and shrinking the mucosa. Cocaine in the form of cocaine hydrochloride is...
Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia
One of the advantages of...
Local Anesthetics: Clinical Application as Surface, Infiltration, and Conduction Block Anesthesia
Local Anesthetics: Clinical Application as Spinal Anesthesia
Local Anesthetics: Clinical Application as Epidural Anesthesia
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
Local Anesthetics: Pharmacokinetics

