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[The regulation of gene expression by glucose]
Jean Girard1, Renaud Dentin, Fadila Benhamed
1INSERM U567, CNRS UMR 8104, Université Paris Descartes, Département d'Endocrinologie, Métabolisme et Cancer, Faculté de Médecine Cochin, 24, rue du Faubourg Saint-Jacques, 75014 Paris. girard@cochin.inserm.fr
Abstract:
Glucose should not be considered uniquely as a cellular fuel but also as a signaling molecule involved in the regulation of genes encoding glycolytic and lipogenic enzymes and, as such, in storage of triglycerides. Transcriptional effects of glucose on glycolytic and lipogenic enzymes involve a specific transcription factor, ChREBP, whose characteristics and mechanism of activation are described. Finally, the possible implication of ChREBP in the physiopathology of obesity and type 2 diabetes are discussed.
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