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Pharmacologic...
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Related Experiment Video

Updated: Jul 10, 2026

Equine Enteric Glial Culture and Application to the Study of a Neural Inflammatory Mechanism in Equine Colic
08:07

Equine Enteric Glial Culture and Application to the Study of a Neural Inflammatory Mechanism in Equine Colic

Published on: October 4, 2024

Update on infantile colic and management options.

Sandeep K Gupta1

  • 1James Whitcomb Riley Hospital for Children, Indiana University School of Medicine, Division of Pediatric Gastroenterology/Hepatology/Nutrition, Room ROC 4210, 702 Barnhill Drive, Indianapolis, IN 46202-5225, USA. sgupta@iupui.edu

Current Opinion in Investigational Drugs (London, England : 2000)
|November 6, 2007
PubMed
Summary

Infant colic may stem from food allergies and gut motility issues, often requiring a multifaceted management approach. A biopsychosocial strategy is recommended for infants and families, considering medical conditions and family dynamics.

Related Experiment Videos

Last Updated: Jul 10, 2026

Equine Enteric Glial Culture and Application to the Study of a Neural Inflammatory Mechanism in Equine Colic
08:07

Equine Enteric Glial Culture and Application to the Study of a Neural Inflammatory Mechanism in Equine Colic

Published on: October 4, 2024

Area of Science:

  • Pediatrics
  • Gastroenterology
  • Developmental Psychology

Background:

  • Infant colic is a common, poorly understood condition with multiple proposed causes.
  • Key contenders for causation include food hypersensitivity/allergy and gut dysmotility.
  • Psychosocial factors also contribute as confounders and covariables.

Purpose of the Study:

  • To review the pathogenesis of infantile colic.
  • To discuss interventions based on perceived causes.
  • To emphasize a multifactorial management strategy.

Main Methods:

  • Literature review of infantile colic pathogenesis and management.
  • Analysis of proposed causative factors including dietary protein intolerance and gut motility disturbances.
  • Discussion of a biopsychosocial approach to infant and family care.

Main Results:

  • Hypothesizes predisposition to dietary protein intolerance and disturbed gut motility in some infants.
  • Suggests altered perceptions where normal stimuli are misinterpreted as painful.
  • Highlights the need for a multifactorial management strategy, including caregiver support.

Conclusions:

  • Infantile colic likely involves a combination of factors, including potential predisposition to gut issues and altered sensory perception.
  • A comprehensive biopsychosocial approach is crucial for managing infants and families.
  • While most infants recover, some may face later issues like behavioral problems or allergies.