A cellular Trojan Horse for delivery of therapeutic nanoparticles into tumors
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Updated: Jul 10, 2026

Nanoparticle Delivery of an Oligonucleotide Payload in a Glioblastoma Multiforme Animal Model
Published on: September 27, 2024
Mi-Ran Choi1, Katie J Stanton-Maxey, Jennifer K Stanley
1Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Abstract:
Destruction of hypoxic regions within tumors, virtually inaccessible to cancer therapies, may well prevent malignant progression. The tumor's recruitment of monocytes into these regions may be exploited for nanoparticle-based delivery. Monocytes containing therapeutic nanoparticles could serve as "Trojan Horses" for nanoparticle transport into these tumor regions. Here we report the demonstration of several key steps toward this therapeutic strategy: phagocytosis of Au nanoshells, and photoinduced cell death of monocytes/macrophages as isolates and within tumor spheroids.
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