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Related Experiment Videos

Site-specific morphologic differences in extranodal marginal zone B-cell lymphomas.

Ajay Rawal1, William G Finn, Bertram Schnitzer

  • 1Department of Pathology, Minneapolis Veterans Affairs Medical Center, Minneapolis, Minn, USA.

Archives of Pathology & Laboratory Medicine
|November 6, 2007
PubMed
Summary
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Lymphoepithelial lesions (LELs) vary by site in extranodal marginal zone B-cell lymphoma (EMZL). Site-specific patterns of LELs, CD43, and plasma cells can aid EMZL diagnosis.

Area of Science:

  • Oncology
  • Pathology
  • Immunohistochemistry

Background:

  • Lymphoepithelial lesions (LELs) are key in diagnosing extranodal marginal zone B-cell lymphoma (EMZL).
  • Limited data exists on LEL frequency and morphology across different anatomical sites in EMZL.

Purpose of the Study:

  • To identify diagnostically useful, site-specific morphologic patterns in EMZLs.
  • To compare the frequency and characteristics of LELs in EMZL across various locations.

Main Methods:

  • Retrospective review of 136 EMZL cases from diverse sites.
  • Evaluation of LEL patterns, CD43 coexpression, and plasma cell component features.

Main Results:

  • Prominent LELs were frequent in salivary and thyroid glands, rare in breast, skin, and ocular adnexa.

Related Experiment Videos

  • Specific LEL patterns (lymphocytes stuffing lumina) observed in lung, thyroid, and salivary glands.
  • Monoclonal plasma cells common in breast, URT, skin, and salivary glands; CD43 coexpression in 36% (salivary, stomach, URT most common).

    • Conclusions:

    • LEL patterns, CD43 coexpression, and clonal plasma cell presence are site-dependent in EMZL.
    • These site-specific differences can assist in diagnosing EMZL at various anatomical locations.