Clinical pharmacogenetics in pediatric patients

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Anwar Husain1, Jennifer A Loehle, David W Hein

  • 1University of Louisville, Department of Pharmacology & Toxicology and James Graham Brown Center, School of Medicine, Louisville, KY, USA.

Pharmacogenomics
|November 6, 2007
PubMed

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In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...
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Pharmacokinetics in Pediatric Patients: Drug Excretion

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