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Updated: Jul 10, 2026

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia
Published on: November 30, 2016
Emerging drugs for cancer cachexia
Josep M Argilés1, Francisco J López-Soriano, Sílvia Busquets
1Universitat de Barcelona, Cancer Research Group, Departament de Bioquímica i Biologia Molecular, Facultat de Biologia, Diagonal 645, 08071-Barcelona, Spain. jargiles@ub.edu
Abstract:
Cachexia is a complex syndrome. The main components of this pathological state are anorexia and metabolic abnormalities such as glucose intolerance, fat depletion and muscle protein catabolism among others. The altered metabolic status generates a high degree of energetic inefficiency that results in weight loss, fatigue and a considerable loss of muscle and, therefore, asthenia. The aim of the present article is to review the different therapeutic approaches and emerging drugs that have been designed to fight and counteract cachexia associated with cancer.
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