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Updated: Jul 10, 2026

Bacterial Artificial Chromosomes: A Functional Genomics Tool for the Study of Positive-strand RNA Viruses

Bacterial Artificial Chromosomes: A Functional Genomics Tool for the Study of Positive-strand RNA Viruses

Published on: December 29, 2015

Baculovirus genomics.

Monique M van Oers¹, Just M Vlak

¹Laboratory of Virology, Wageningen University, Binnenhaven 11, 6709 PD Wageningen, The Netherlands. monique.vanoers@wur.nl

Current Drug Targets

|November 6, 2007

Summary

This summary is machine-generated.

Baculovirus genomes, double-stranded DNA viruses, exhibit conserved core genes and structural plasticity. Their genomes are tightly packed, with variations arising from recombination and gene insertions, impacting host specificity.

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Area of Science:

* Virology
* Molecular Biology
* Genomics

Background:

* Baculoviruses are double-stranded DNA viruses with circular genomes.
* Over 41 baculovirus genomes have been sequenced, primarily infecting Lepidoptera, but also Hymenoptera and Diptera.
* Genome sequencing reveals general patterns in structure and gene content.

Purpose of the Study:

* To review the structural and functional properties of baculovirus genomes.
* To highlight conserved and variable genes within baculovirus genomes.
* To discuss genomic plasticity and factors influencing it.

Main Methods:

* Comparative genomics based on available sequenced baculovirus genomes.
* Analysis of genome structure, gene organization, and conserved gene sets.
* Examination of genomic variations, recombination, and transposon activity.

Main Results:

* Baculovirus genomes are tightly packed with minimal intergenic regions and genes distributed across both strands.
* A conserved set of 29 core genes is characteristic of baculoviruses.
* Homologous regions with repeats and palindromic motifs are common, aiding transcription and replication.
* Genomic plasticity is evident, with recombination and transposon insertions contributing to gene acquisition.

Conclusions:

* Baculovirus genomes display both conserved features and significant plasticity.
* Understanding genome structure and variation is crucial for baculovirus research and application.
* Factors like recombination and transposons drive baculovirus evolution and host range.