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Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers
Published on: October 17, 2013
Tight junction modulators: promising candidates for drug delivery
1Department of Bio-Functional Molecular Chemistry, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565-0871, Japan. masuo@phs.osaka-u.ac.jp
Current Medicinal Chemistry
|November 6, 2007
Summary
Novel drug delivery strategies leverage advances in genomic drug development and high-throughput screening. These methods target the paracellular pathway by understanding tight junction (TJ) biology for enhanced therapeutic compound transport.
Area of Science:
- Pharmacology
- Cell Biology
- Drug Delivery Systems
Background:
- Genomic drug development and high-throughput screening accelerate the identification of pharmaceutically active compounds.
- The paracellular pathway offers a promising route for drug delivery, but is restricted by tight junctions (TJs).
- TJs play a critical role in regulating solute movement between adjacent cells.
Purpose of the Study:
- To review drug delivery strategies targeting the paracellular pathway.
- To discuss the role of tight junction biology in drug transport.
- To explore future directions for TJ-component-based drug delivery systems.
Main Methods:
- Review of recent advances in genomic drug development and high-throughput screening.
- Analysis of the biochemical and functional structure of tight junctions.
- Examination of the roles of occludin, claudins, and tricellulin in TJ barrier regulation.
Main Results:
- Progress in TJ biology provides new insights into TJ structure and function.
- Understanding TJ components like occludin, claudins, and tricellulin is key to manipulating TJ barriers.
- Novel strategies for paracellular drug delivery based on TJ components have been developed.
Conclusions:
- Targeting tight junctions offers a viable strategy for enhancing paracellular drug delivery.
- Further research into TJ-component-based systems holds significant potential for future drug delivery applications.
- Integrating advances in genomics and high-throughput screening with TJ biology is crucial for developing effective drug delivery systems.
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