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Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...

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Related Experiment Video

Updated: Jul 10, 2026

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
10:28

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

Published on: September 20, 2018

Targeting epigenetic modifiers in cancer.

A F Holloway1, P C Oakford

  • 1Menzies Research Institute, University of Tasmania, Hobart, Tasmania 7001, Australia. A.F.Holloway@utas.edu.au

Current Medicinal Chemistry
|November 6, 2007
PubMed
Summary
This summary is machine-generated.

Epigenetic modifications regulate gene expression and are crucial in cancer. Inhibitors targeting these epigenetic complexes offer promising, reversible therapeutic strategies for cancer treatment.

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Epigenetic Engineering of K562 Cells: Dual-Vector Episomal Strategy for Stable Targeted DNA Methylation using dCas9-DNMT3A and -HDAC1 Fusion Proteins
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Published on: April 5, 2018

Area of Science:

  • Molecular Biology
  • Epigenetics
  • Cancer Biology

Background:

  • Gene expression is regulated by chromatin structure, influenced by epigenetic modifications.
  • Epigenetic changes, alongside genetic alterations, contribute to aberrant gene expression in cancer.
  • Epigenetic modifications are reversible, making them attractive therapeutic targets.

Purpose of the Study:

  • To review recent literature on protein complexes catalyzing epigenetic modifications.
  • To discuss inhibitors of these complexes as cancer drug candidates.
  • To highlight promising epigenetic targets lacking current inhibitors.

Main Methods:

  • Literature review of recent scientific publications.
  • Analysis of protein complexes involved in epigenetic regulation.
  • Examination of existing and potential therapeutic inhibitors.

Main Results:

  • Identified key protein complexes responsible for epigenetic modifications.
  • Cataloged inhibitors currently in development for cancer therapy.
  • Highlighted epigenetic modifiers with therapeutic potential but no available inhibitors.

Conclusions:

  • Epigenetic modifiers are crucial in cancer and represent viable therapeutic targets.
  • Inhibitors targeting epigenetic complexes offer reversible treatment options.
  • Further research is needed to develop inhibitors for promising, yet untargeted, epigenetic modifiers.