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Updated: Jul 10, 2026

Extraction of Venom and Venom Gland Microdissections from Spiders for Proteomic and Transcriptomic Analyses
Published on: November 3, 2014
Snake venom components affecting blood coagulation and the vascular system: structural similarities and marked
Yasuo Yamazaki1, Takashi Morita
1Department of Biochemistry, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan.
Abstract:
In studies of blood coagulation and the vascular system, snake venom toxins have been indispensable in elucidating the complex physiological mechanisms that govern coagulation and the vascular system in mammals, given their potency and highly specific biological effects. The various components of snake venom toxins can be classified according to their mechanism of action, for example, serine proteases, metalloproteinases, Kunitz-type protease inhibitors, phospholipases A(2), (L)-amino acid oxidases, C-type lectin(-like) proteins, disintegrins, vascular endothelial growth factors, three-finger toxins, and cysteine-rich secretory proteins. Although the molecular structures of most toxins are not unique to snake venom toxins, venom proteins often exhibit marked diversity in their biological effects, despite their structural similarities. In this review, we identify several snake venom toxins capable of affecting blood coagulation and the vascular system, as well as various toxins from other organisms, including leeches and ticks.
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