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Updated: Jul 10, 2026

Detecting the Ligand-binding Domain Dimerization Activity of Estrogen Receptor Alpha Using the Mammalian Two-Hybrid Assay
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Effect of heterodimer partner RXRalpha on PPARgamma activation function-2 helix in solution

Jianyun Lu1, Minghe Chen, Susan E Stanley

  • 1Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA. lujy@wustl.edu

Biochemical and Biophysical Research Communications
|November 6, 2007
PubMed
Summary

Nuclear magnetic resonance (NMR) reveals how retinoid X receptor (RXR) binding influences peroxisome proliferator-activated receptor gamma (PPARgamma). This study provides insights into allosteric ligand activation in RXR heterodimers.

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