Preparation and in vitro evaluation of salbutamol sulphate microcapsules

Microcapsules of salbutamol sulphate were prepared using cellulose acetate phthalate as a coating material and by the coacervation phase separation (solvent evaporation) technique for obtaining sustained action. Prepared microcapsules were evaluated for their drug content, physical properties, release characteristics and stability. The effect of coat to core ratio on release pattern was studied and it was found that microcapsules prepared with coat to core ratio 2:1 were able to retard the release of drug for 12 hours. No significant change was observed in drug content and release pattern even after storage.