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Related Experiment Videos

Prolonged release terbutaline sulphate microcapsules.

N C Manekar1, P K Puranik, S B Joshi

  • 1Department of Pharmaceutical Science, Nagpur University, India.

Journal of Microencapsulation
|October 1, 1991
PubMed
Summary
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Terbutaline sulphate microcapsules were developed using a novel solvent evaporation technique. These microcapsules demonstrated favorable characteristics for potential pharmaceutical applications.

Area of Science:

  • Pharmaceutical Technology
  • Materials Science

Background:

  • Terbutaline sulphate is a bronchodilator used for respiratory conditions.
  • Microencapsulation offers controlled release and improved drug delivery.
  • Developing stable and effective microcapsule formulations is crucial for therapeutic efficacy.

Purpose of the Study:

  • To prepare terbutaline sulphate microcapsules using the coacervation-phase separation technique.
  • To evaluate the impact of cellulose acetate phthalate and ethyl cellulose as coating materials.
  • To assess the physicochemical properties and in vitro dissolution of the prepared microcapsules.

Main Methods:

  • Microencapsulation via coacervation-phase separation induced by solvent evaporation.
  • Coating materials: cellulose acetate phthalate alone and in combination with ethyl cellulose.

Related Experiment Videos

  • Evaluation of drug content, particle size, flow properties, bulk density, and in vitro dissolution.

    • Main Results:

    • Successfully prepared terbutaline sulphate microcapsules with varying coating compositions.
    • Characterization revealed specific particle size distributions and flow properties.
    • In vitro dissolution studies indicated the release profile of terbutaline sulphate from the microcapsules.

    Conclusions:

    • The coacervation-phase separation technique is suitable for preparing terbutaline sulphate microcapsules.
    • Coating materials influence the physicochemical properties and drug release.
    • The developed microcapsules show potential for controlled delivery of terbutaline sulphate.