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Published on: February 10, 2023
Iliofemoral venous thrombosis
Anthony J Comerota1, Marilyn H Gravett
1Jobst Vascular Center, The Toledo Hospital, Toledo, Ohio 43606, USA.
Insights
Iliofemoral deep vein thrombosis (DVT) requires advanced treatment beyond anticoagulation alone. Thrombus removal combined with anticoagulation significantly improves patient outcomes for iliofemoral DVT.
Area of Science:
- Vascular Medicine
- Interventional Cardiology
- Hematology
Background:
- Iliofemoral deep vein thrombosis (DVT) leads to severe short- and long-term consequences.
- Current standard treatment for acute iliofemoral DVT is anticoagulation alone.
- This approach may not be optimal for severe iliofemoral DVT cases.
Purpose of the Study:
- To review evidence supporting thrombus removal for iliofemoral DVT.
- To discuss current and emerging thrombus removal techniques.
- To advocate for improved treatment strategies for iliofemoral DVT.
Main Methods:
- Review of existing medical literature on iliofemoral DVT treatments.
- Analysis of studies comparing anticoagulation alone versus combined therapies.
- Discussion of interventional techniques for thrombus removal.
Main Results:
- Evidence suggests that thrombus removal plus anticoagulation improves outcomes in iliofemoral DVT.
- Contemporary venous thrombectomy is a viable option.
- Catheter-directed thrombolysis and pharmacomechanical thrombolysis show promise.
Conclusions:
- Standard anticoagulation may be insufficient for iliofemoral DVT.
- Integrating thrombus removal into treatment plans can significantly enhance patient outcomes.
- Further research and adoption of advanced techniques are warranted for iliofemoral DVT management.
Abstract:
Iliofemoral deep vein thrombosis (DVT) is associated with serious short- and long-term physical, social, and economic sequelae for patients. Most physicians treat patients with acute iliofemoral DVT in the same manner as they treat all acute DVT patients: with anticoagulation alone. Yet a growing body of evidence suggests that, in this subset of DVT patients, a treatment strategy that includes thrombus removal plus optimal anticoagulation significantly improves outcomes. This article reviews the evidence supporting this strategy and discusses current and promising techniques of thrombus removal, including contemporary venous thrombectomy, intrathrombus catheter-directed thrombolysis, and pharmacomechanical thrombolysis.
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