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Updated: Jul 10, 2026

Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells
Published on: January 29, 2014
[Warm autoimmune hemolytic anemias and Evans syndrome in adults]
1Service de médecine interne, centre de référence pour les cytopénies auto-immunes de l'adulte, CHU Henri-Mondor, 52, avenue du maréchal de Lattre-de-Tassigny, 94010 Créteil, France. marc.michel@hmn.aphp.fr <marc.michel@hmn.aphp.fr>
Purpose:
The outcome of autoimmune hemolytic anemia (AIHA) and Evans syndrome (ES) in adults is not well-known and their management is mainly based on empirical data.
Current Knowledge And Key Points:
The main characteristics of both AIHA and ES are reviewed in this article, based on the data available in the literature and on our experience. Although controlled studies and evidence-based data are lacking, some recommendations regarding the minimal workup useful to search for an underlying disease can be made as well as proposals for a better therapeutic strategy of both disorders.
Future Prospects And Projects:
A better knowledge of the mechanisms triggering AIHA and ES as well as therapeutic trials are needed in order to better stratify treatment taking into account the promising efficacy of rituximab.
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