Related Experiment Video
Updated: Jul 10, 2026

Cell-cell Fusion of Genome Edited Cell Lines for Perturbation of Cellular Structure and Function
Published on: December 7, 2019
Cell fusion during development
Meital Oren-Suissa1, Benjamin Podbilewicz
1Department of Biology, Technion-Israel Institute of Technology, Haifa, 32000 Israel.
Abstract:
Most readers of this review originated from a sperm-egg fusion event. Cell fusion is a process that is crucial at many intersections later during development. However, we do not know which molecules (fusogens) fuse the membranes of gametes to form zygotes, myoblasts to form myotubes in muscles, macrophages to form osteoclasts in bones, or cytotrophoblasts to form syncytiotrophoblasts in placentas. There are five gold standards that can be applied for the identification of genuine fusogens. Based on these criteria, a numerical score can be used to assess the likelihood of protein fusogenicity. We compare distinct families of candidate developmental, viral and intracellular fusogens and analyze current models of membrane fusion.
Related Concept Videos
Cleavage and Blastulation
Zygotic Development And Stem Cell Formation
Mitosis and Cytokinesis
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...
Mitosis and Cytokinesis
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...
Enlargement of the Plasma Membrane
Cell Migration

