Monoclonal antibodies in the treatment of advanced colorectal cancer

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Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies
09:29

Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies

Published on: September 30, 2016

J Capdevila1, C Saura, T Macarulla

  • 1Medical Oncology Department, Vall d'Hebron University Hospital, P. Vall d'Hebron 119-129, 08035 Barcelona, Spain.

European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
|November 6, 2007
PubMed

Insights

Monoclonal antibodies offer new hope for metastatic colorectal cancer patients. This review details their development and optimal use against advanced colorectal cancer, improving poor prognoses.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Metastatic colorectal cancer (mCRC) still has a poor prognosis despite treatment advances.
  • Understanding molecular pathways in mCRC has identified new therapeutic targets.
  • Novel drug development offers new treatment opportunities for mCRC patients.

Purpose of the Study:

  • To review the current development status of monoclonal antibodies for advanced colorectal cancer.
  • To discuss the optimization and best use of novel therapeutic approaches in mCRC.

Main Methods:

  • Review of clinical development data for monoclonal antibodies in advanced colorectal cancer.
  • Analysis of emerging data on targeted therapies for mCRC.

Main Results:

  • Monoclonal antibodies represent a significant advancement in mCRC treatment.
  • New targeted therapies are emerging with clinical development data.

Conclusions:

  • Monoclonal antibodies are a promising therapeutic strategy for advanced colorectal cancer.
  • Further research is needed to optimize the use of these novel agents in mCRC treatment.

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