Related Experiment Video
Updated: Jul 10, 2026

14:34
A Bilingual Computational Workflow for Identifying Potential PLK1 Inhibitors in American Sign Language and English
Published on: April 3, 2026
Biphenyl amide p38 kinase inhibitors 2: Optimisation and SAR
Richard M Angell1, Tony D Angell, Paul Bamborough
1GlaxoSmithKline R&D, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK.
Bioorganic & Medicinal Chemistry Letters
|November 6, 2007
Abstract:
The biphenyl amides are a novel series of p38 MAP kinase inhibitors. Structure-activity relationships of the series against p38alpha are discussed with reference to the X-ray crystal structure of an example. The series was optimised rapidly to a compound showing oral activity in an in vivo disease model.
