Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jul 10, 2026

A Standardized Pig to Macaque Heterotopic Heart Xenotransplantation Model
06:52

A Standardized Pig to Macaque Heterotopic Heart Xenotransplantation Model

Published on: November 4, 2025

Progress towards clinical xenotransplantation.

Henk-Jan Schuurman1, Richard N Pierson

  • 1Spring Point Project, 121 South 8th Street Suite 825, Minneapolis, MN 55402, USA. hschuurman@springpointproject.org

Frontiers in Bioscience : a Journal and Virtual Library
|November 6, 2007
PubMed
Summary

Pig organs show promise for transplantation, overcoming hyperacute rejection. Challenges remain in immunosuppression and safety for widespread clinical use, though islet cell transplantation is nearing trials.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Vatican Revisits Ethics and Science of Xenotransplantation as Clinical Trials Advance.

The Linacre quarterly·2026
Same author

Vatican Reaffirms Moral Permissibility of Xenotransplantation.

Xenotransplantation·2026
Same author

Perspectives on the 2026 ISHLT Consensus Statement on Clinical Cardiac Xenotransplantation.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation·2026
Same author

Advancing Hope Through Science: The Inaugural Richard Slayman International Workshop on Xenotransplantation.

Transplantation·2026
Same author

Pig Lung Xenotransplantation: Barriers on the Road to Clinical Translation.

Transplant international : official journal of the European Society for Organ Transplantation·2026
Same author

Correction: Leukocyte dynamics in <i>Cynomolgus</i> monkeys following heterotopic heart allotransplantation under costimulation pathway blockade.

Frontiers in immunology·2025

Area of Science:

  • Biomedical Engineering
  • Transplantation Immunology
  • Regenerative Medicine

Background:

  • Xenotransplantation is crucial for meeting organ demand in end-stage organ failure.
  • Pigs are the most promising donor species, but evolutionary distance requires innovative solutions.
  • Non-human primate studies advanced understanding of rejection and immunosuppression.

Purpose of the Study:

  • To review progress in xenotransplantation, focusing on overcoming immunological barriers.
  • To discuss current challenges in immunosuppression and safety for clinical application.
  • To highlight the potential of porcine xenografts, particularly islets of Langerhans.

Main Methods:

  • Review of advancements in genetic modification of donor animals (e.g., transgenic pigs).

More Related Videos

Quantification of Circulating Pig-Specific DNA in the Blood of a Xenotransplantation Model
07:34

Quantification of Circulating Pig-Specific DNA in the Blood of a Xenotransplantation Model

Published on: September 22, 2020

Related Experiment Videos

Last Updated: Jul 10, 2026

A Standardized Pig to Macaque Heterotopic Heart Xenotransplantation Model
06:52

A Standardized Pig to Macaque Heterotopic Heart Xenotransplantation Model

Published on: November 4, 2025

Quantification of Circulating Pig-Specific DNA in the Blood of a Xenotransplantation Model
07:34

Quantification of Circulating Pig-Specific DNA in the Blood of a Xenotransplantation Model

Published on: September 22, 2020

  • Analysis of strategies to prevent hyperacute rejection, including complement inhibition.
  • Evaluation of safety concerns, such as porcine endogenous retrovirus transmission.

    • Main Results:

    • Genetic modifications have largely eliminated hyperacute rejection of solid porcine organs.
    • Tolerable immunosuppression and immune-tolerance regimens are still needed for broad clinical use.
    • Porcine islet of Langerhans transplantation is nearing clinical trials for diabetes.

    Conclusions:

    • Significant progress has been made in xenotransplantation, particularly in reducing hyperacute rejection.
    • Further research is essential to establish safe and effective immunosuppression for widespread clinical xenotransplantation.
    • Porcine xenografts hold significant therapeutic potential, with islet transplantation being the most immediate application.