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Assessment of Sarcoplasmic Reticulum Calcium Reserve and Intracellular Diastolic Calcium Removal in Isolated Ventricular Cardiomyocytes
Published on: September 18, 2017
Exercise-induced changes in calcium handling in left ventricular cardiomyocytes
Ole J Kemi1, Oyvind Ellingsen, Godfrey L Smith
1Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, UK. o.kemi@bio.gla.ac.uk
Frontiers in Bioscience : a Journal and Virtual Library
|November 6, 2007
Summary
Regular exercise training enhances heart contractile function by improving cardiomyocyte performance and calcium handling. This adaptation benefits both healthy individuals and those with heart failure, restoring cardiac function.
Area of Science:
- Cardiology
- Exercise Physiology
- Cellular Biology
Background:
- Regular exercise training beneficially adapts the heart, enhancing contractile capacity.
- These adaptations are crucial for both healthy individuals and those with compromised myocardial function, such as in heart failure.
Purpose of the Study:
- To elucidate the cellular mechanisms by which exercise training improves cardiac contractile function.
- To understand how exercise training impacts cardiomyocyte function in the context of heart failure.
Main Methods:
- Utilized experimental animal models of exercise training and heart failure.
- Employed biophysical and biochemical characterization of heart function at the cellular level.
Main Results:
- Exercise training increased cardiomyocyte strength of contraction, shortening, and relengthening rates.
- Enhanced myocardial force production and power output were observed, linked to faster intracellular calcium transient dynamics and improved myofilament calcium sensitivity.
- Cellular improvements translated to enhanced left ventricular systolic and diastolic function.
Conclusions:
- Exercise training restores depressed contractility and calcium cycling in heart failure to levels comparable to healthy individuals.
- Cellular adaptations in cardiomyocytes underpin the global improvements in cardiac function observed after exercise training.
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