Biochips: non-conventional strategies for biosensing elements immobilization
Christophe A Marquette1, Benjamin P Corgier, Kevin A Heyries
1Laboratoire de Genie Enzymatique et Biomoleculaire, UMR 5246 ICBMS, CNRS-Universite Claude Bernard Lyon 1, Bat CPE, 43, bd du 11 novembre 1918, 69622 Villeurbanne, Cedex, France. christophe.marquette@univlyon1.fr
Abstract:
The present article draws a general picture of non-conventional methods for biomolecules immobilization. The technologies presented are based either on original solid supports or on innovative immobilization processes. Polydimethylsiloxane elastomer will be presented as a popular immobilization support within the biochip developer community. Electro-addressing of biomolecules at the surface of conducting biochips will appear to be an interesting alternative to immobilization processes based on surface functionalization. Finally, bead-assisted biomolecules immobilization will be presented as an open field of research for biochip developments.
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