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Related Concept Videos

Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
Renal Failure: Dose Adjustments01:11

Renal Failure: Dose Adjustments

In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Acute Kidney Injury VI: Nursing Management01:22

Acute Kidney Injury VI: Nursing Management

Acute Kidney Injury (AKI) results in an inability to maintain fluid, electrolyte, and acid-base balance. Effective nursing management is critical in improving patient outcomes and includes comprehensive patient assessment and targeted interventions.Comprehensive Patient AssessmentA detailed history collection is essential, focusing on any recent infections, nephrotoxic medication use, or chronic conditions such as hypertension and diabetes that may contribute to AKI. During the physical...

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Related Experiment Video

Updated: Jul 10, 2026

Renal Ischaemia Reperfusion Injury: A Mouse Model of Injury and Regeneration
12:27

Renal Ischaemia Reperfusion Injury: A Mouse Model of Injury and Regeneration

Published on: June 7, 2014

TWEAKing renal injury.

Ana Belen Sanz1, Juan Antonio Moreno, Maria Dolores Sanchez-Nino

  • 1Fundacion Jimenez Diaz, Universidad Autonoma de Madrid, 2040 Madrid, Spain.

Frontiers in Bioscience : a Journal and Virtual Library
|November 6, 2007
PubMed
Summary

Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) and its receptor Fn14 are implicated in kidney injury. Elevated TWEAK/Fn14 expression in acute kidney injury and lupus nephritis suggests TWEAK as a potential therapeutic target.

Related Experiment Videos

Last Updated: Jul 10, 2026

Renal Ischaemia Reperfusion Injury: A Mouse Model of Injury and Regeneration
12:27

Renal Ischaemia Reperfusion Injury: A Mouse Model of Injury and Regeneration

Published on: June 7, 2014

Area of Science:

  • Immunology
  • Nephrology
  • Cell Biology

Background:

  • TWEAK, a TNF superfamily cytokine, binds Fn14 receptor to regulate cellular processes.
  • Increased TWEAK and Fn14 expression is observed in acute kidney injury (AKI) tubular cells.
  • Elevated urinary TWEAK levels are found in active lupus nephritis patients.

Purpose of the Study:

  • To investigate the role of TWEAK and Fn14 in kidney injury.
  • To explore TWEAK's effects on glomerular mesangial and renal tubular epithelial cells.
  • To assess TWEAK as a potential therapeutic target in kidney diseases.

Main Methods:

  • Analysis of TWEAK and Fn14 expression in kidney injury models.
  • Assessment of Fn14 receptor expression in mesangial and tubular cells.
  • Evaluation of TWEAK's impact on cell death and inflammatory mediator secretion.

Main Results:

  • Glomerular mesangial cells and renal tubular epithelial cells express Fn14.
  • TWEAK induces apoptosis and inflammatory mediator secretion in a proinflammatory context.
  • TWEAK plays a role in both glomerular and tubulointerstitial kidney injury.

Conclusions:

  • TWEAK is a significant factor in kidney injury at multiple levels.
  • TWEAK and its receptor Fn14 are promising targets for therapeutic intervention in kidney diseases.
  • Further research into TWEAK-targeted therapies for kidney conditions is warranted.