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Related Concept Videos

Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...
Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...
Bone Remodeling and Repair01:31

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...

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Visualizing Angiogenesis by Multiphoton Microscopy In Vivo in Genetically Modified 3D-PLGA/nHAp Scaffold for Calvarial Critical Bone Defect Repair
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Visualizing Angiogenesis by Multiphoton Microscopy In Vivo in Genetically Modified 3D-PLGA/nHAp Scaffold for Calvarial Critical Bone Defect Repair

Published on: September 7, 2017

Bone tissue engineering and repair by gene therapy.

Volker M Betz1, Oliver B Betz, Mitchel B Harris

  • 1Center for Molecular Orthopaedics, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA. vbetz@rics.bwh.harvard.edu

Frontiers in Bioscience : a Journal and Virtual Library
|November 6, 2007
PubMed
Summary

Gene therapy offers a promising solution for bone repair, overcoming limitations of protein-based treatments. This approach utilizes gene transfer for effective bone regeneration and enhanced healing in preclinical models.

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Peptides from Phage Display Library Modulate Gene Expression in Mesenchymal Cells and Potentiate Osteogenesis in Unicortical Bone Defects

Published on: December 10, 2010

Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Gene Therapy

Background:

  • Bone growth stimulation is crucial for treating various clinical conditions.
  • Recombinant bone morphogenetic proteins face challenges in delivery and cost-effectiveness.
  • Gene therapy presents a viable alternative, addressing limitations of protein-based treatments.

Purpose of the Study:

  • To review current gene therapy strategies for bone tissue engineering and repair.
  • To highlight the potential of gene-enhanced tissue engineering for clinical applications.

Main Methods:

  • Review of preclinical studies on gene transfer for osteogenic molecule delivery.
  • Discussion of in-vivo and ex-vivo cell transduction techniques.
  • Analysis of genetic engineering of adult stem cells with osteogenic genes.

Main Results:

  • Gene transfer technology enables precise delivery of osteogenic molecules for sustained therapeutic effects.
  • Both in-vivo and ex-vivo gene transfer can induce bone formation at various sites.
  • Genetically engineered stem cells have shown enhanced fracture repair and bone defect healing in animal models.

Conclusions:

  • Gene therapy is a powerful tool for bone repair and tissue engineering.
  • Gene-enhanced tissue engineering holds significant potential for future clinical use.
  • Further research and development are needed to translate these findings into widespread clinical practice.