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Erratum for Gorr, "Resisting the resistance: the antimicrobial peptide DGL13K selects for small colony variants of <i>Staphylococcus aureus</i> that show increased resistance to its stereoisomer LGL13K, but not to DGL13K".

Journal of bacteriology·2026
Same author

Correction: Gorr, S.-U. Targeted Modification of the Antimicrobial Peptide DGL13K Reveals a Naturally Optimized Sequence for Topical Applications. <i>Microorganisms</i> 2025, <i>13</i>, 2355.

Microorganisms·2026
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Targeted Modification of the Antimicrobial Peptide DGL13K Reveals a Naturally Optimized Sequence for Topical Applications.

Microorganisms·2025
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Resisting the resistance: the antimicrobial peptide DGL13K selects for small colony variants of <i>Staphylococcus aureus</i> that show increased resistance to its stereoisomer LGL13K, but not to DGL13K.

Journal of bacteriology·2025
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The oral pathogen Porphyromonas gingivalis gains tolerance to the antimicrobial peptide DGL13K by synonymous mutations in hagA.

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Introduction to the Diagnostics in Periodontology and Implant Dentistry issue.

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Related Experiment Video

Updated: Jul 10, 2026

Organotypic Tissue Model Systems for Investigating Host-Pathogen Interactions In Vitro
08:41

Organotypic Tissue Model Systems for Investigating Host-Pathogen Interactions In Vitro

Published on: March 28, 2025

P. gingivalis interactions with epithelial cells.

Denis F Kinane1, Johnah Cortez Galicia, Sven-Ulrik Gorr

  • 1Oral Health and Systemic Disease Research Group, University of Louisville School of Dentistry, 501 S Preston St., KY 40292, USA. denis.kinane@louisville.edu

Frontiers in Bioscience : a Journal and Virtual Library
|November 6, 2007
PubMed
Summary
This summary is machine-generated.

Dental plaque biofilms initiate periodontal disease by triggering an inflammatory response in gingival epithelial cells. This review explores early bacterial interactions, epithelial cell responses, and their ultimate fate.

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Isolation, Processing and Analysis of Murine Gingival Cells
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Isolation, Processing and Analysis of Murine Gingival Cells

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Porphyromonas gingivalis as a Model Organism for Assessing Interaction of Anaerobic Bacteria with Host Cells
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Isolation, Processing and Analysis of Murine Gingival Cells
09:47

Isolation, Processing and Analysis of Murine Gingival Cells

Published on: July 2, 2013

Area of Science:

  • Oral microbiology
  • Immunology
  • Cell biology

Background:

  • Dental plaque is a complex microbial biofilm on teeth.
  • Biofilm bacteria and byproducts cause gingival inflammation, leading to periodontal disease and tooth loss.
  • Epithelial cell perturbation is the initial step in inflammatory and immune processes.

Purpose of the Study:

  • To review early bacterial-epithelial cell interactions in periodontal disease initiation.
  • To discuss epithelial cell responses to bacterial challenges.
  • To examine the role of Toll-like receptors (TLRs) and antimicrobial peptides.

Main Methods:

  • Literature review of studies on bacterial-epithelial cell interactions.
  • Analysis of inflammatory and immune responses.
  • Discussion of signaling pathways and cellular fate.

Main Results:

  • Epithelial Toll-like receptors (TLRs) recognize diverse bacterial challenges.
  • Variable antimicrobial peptides are released in response to bacterial stimuli.
  • Host signaling pathways modulate epithelial cell survival, apoptosis, or lysis.

Conclusions:

  • Early bacterial-epithelial cell interactions are critical in periodontal disease pathogenesis.
  • Understanding TLRs and antimicrobial peptide responses informs therapeutic strategies.
  • Epithelial cell fate (survival, apoptosis, lysis) influences disease progression.