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Induction of Graft-versus-host Disease and In Vivo T Cell Monitoring Using an MHC-matched Murine Model
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Published on: August 29, 2012

Role of dendritic cells and chemokines in acute graft-versus-host disease

Jingwei Xu1, Tong Zhou, Yanyun Zhang

  • 1Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

Frontiers in Bioscience : a Journal and Virtual Library
|November 6, 2007
PubMed

Graft-versus-host disease (GVHD) is a major complication of allogeneic bone marrow transplantation. GVHD is caused by donor T cells that recognize and react to recipient histocompatibility differences, resulting in significant morbidity and mortality. The pathophysiology of GVHD is complex, which occurs in three phases: induction phase, activation phase and effector phase. Numerous studies have demonstrated that GVHD involves multiple inflammatory cells and cytokines, in particular of antigen presenting cells, chemokines and T cell subsets. This review will discuss roles of a special antigen presenting cell: dendritic cell and chemokines in T cell-mediated acute GVHD.

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