Gene therapy in prostate cancer: past, present and future

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Virus Delivery of CRISPR Guides to the Murine Prostate for Gene Alteration
06:21

Virus Delivery of CRISPR Guides to the Murine Prostate for Gene Alteration

Published on: April 27, 2018

Toshiro Shirakawa1, Masato Fujisawa, Akinobu Gotoh

  • 1Division of Infectious Disease Control, International Center for Medical Research and Treatment, Kobe University School of Medicine, Japan. toshiro@med.kobe-u.ac.jp

Frontiers in Bioscience : a Journal and Virtual Library
|November 6, 2007
PubMed

Insights

Gene therapy offers a promising approach for hormone-refractory prostate cancer, with numerous clinical trials demonstrating its potential. This review examines past trials and future prospects for this advanced cancer treatment.

Area of Science:

  • Oncology
  • Gene Therapy
  • Prostate Cancer Research

Background:

  • Hormone-refractory prostate cancer lacks effective treatments, necessitating novel therapeutic strategies.
  • Gene therapy presents a viable option, alone or combined with existing treatments for advanced prostate cancer.

Purpose of the Study:

  • To review historical clinical trials of prostate cancer gene therapy.
  • To predict future directions and potential of gene therapy for prostate cancer.

Main Methods:

  • Chronological review of prostate cancer gene therapy clinical trials since 1994.
  • Analysis of the suitability of gene therapy for prostate cancer treatment.

Main Results:

  • Approximately 80 prostate cancer gene therapy protocols have been implemented.
  • Prostate cancer is amenable to gene therapy due to easy monitoring (serum-PSA), ultrasound-guided local access, and organ immunogenicity.

Conclusions:

  • Prostate cancer gene therapy is an increasingly researched area with growing clinical trial numbers.
  • Gene therapy holds significant promise for treating advanced prostate cancer.

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