Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

EpCAM expression in normal, non-pathological tissues.

Eva Schmelzer1, Lola M Reid

  • 1Leipzig University, Biotechnological-Biomedical Center, Department of Cell Culture and Stem Cell Biology, Deutscher Platz 5, 04103 Leipzig, Germany.

Frontiers in Bioscience : a Journal and Virtual Library
|November 6, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Author Correction: Organ-specific metastases obtained by culturing colorectal cancer cells on tissue-specific decellularized scaffolds.

Nature biomedical engineering·2025
Same author

Decellularized liver scaffolds for constructing drug-metabolically functional <i>ex vivo</i> human liver models.

Bioactive materials·2024
Same author

Corrigendum to "Fibrolamellar carcinomas-growth arrested by paracrine signals complexed with synthesized 3-O sulfated heparan sulfate oligosaccharides" [Matrix Biology 121(August 2023), 194-216].

Matrix biology : journal of the International Society for Matrix Biology·2024
Same author

Fibrolamellar carcinomas-growth arrested by paracrine signals complexed with synthesized 3-O sulfated heparan sulfate oligosaccharides.

Matrix biology : journal of the International Society for Matrix Biology·2023
Same author

Liver cell therapies: cellular sources and grafting strategies.

Frontiers of medicine·2023
Same author

Chemical, Molecular, and Single-nucleus Analysis Reveal Chondroitin Sulfate Proteoglycan Aberrancy in Fibrolamellar Carcinoma.

Cancer research communications·2023
Same journal

The CD44 protein family: roles in embryogenesis and tumor progression.

Frontiers in bioscience : a journal and virtual library·2017
Same journal

Four varieties of voltage-gated proton channels.

Frontiers in bioscience : a journal and virtual library·2017
Same journal

Lurie's tubercle-count method to test TB vaccine efficacy in rabbits.

Frontiers in bioscience : a journal and virtual library·2017
Same journal

Optical spectroscopy of breast biopsies and human breast cancer xenografts in nude mice.

Frontiers in bioscience : a journal and virtual library·2017
Same journal

The colostrum-deprived, artificially-reared, neonatal pig as a model animal for studying rotavirus gastroenteritis.

Frontiers in bioscience : a journal and virtual library·2017
Same journal

Action of polypeptide growth factors in colon cancer; development of new therapeutic approaches.

Frontiers in bioscience : a journal and virtual library·2017
See all related articles

Epithelial Cell Adhesion Molecule (EpCAM) is present in non-pathological human livers on hepatic progenitors across all ages. These EpCAM-positive liver cells show potential for proliferation and differentiation into mature liver cells.

Area of Science:

  • Hepatology
  • Developmental Biology
  • Cancer Biology

Background:

  • Epithelial Cell Adhesion Molecule (EpCAM) is a transmembrane glycoprotein implicated in various cancers.
  • EpCAM is typically expressed in normal epithelial tissues, with notable exceptions including hepatocytes.
  • EpCAM expression is also observed during early liver development.

Purpose of the Study:

  • To investigate the presence and characteristics of EpCAM expression in non-pathological human livers.
  • To identify EpCAM-positive cells within the hepatic progenitor population.
  • To explore the potential of EpCAM-positive liver cells for regeneration.

Main Methods:

  • Immunohistochemical analysis of human liver tissues from fetal to adult donors.
  • Characterization of EpCAM expression in hepatic stem cells and hepatoblasts.

Related Experiment Videos

  • Xenotransplantation experiments using EpCAM-positive human liver cells.

    • Main Results:

    • EpCAM is expressed in non-pathological human livers on hepatic progenitors (stem cells and hepatoblasts) across all developmental stages.
    • The percentage of EpCAM-positive progenitors varies with donor age, being higher in fetuses (12.1%) than adults (2.5%).
    • Xenotransplantation of EpCAM-positive human liver cells demonstrated their capacity for proliferation and differentiation into mature liver parenchymal cells.

    Conclusions:

    • EpCAM is a reliable marker for hepatic progenitors in non-pathological human livers throughout development.
    • EpCAM-positive hepatic progenitors possess regenerative potential, suggesting their utility in liver disease therapies.
    • Further research into EpCAM's role could advance regenerative medicine and cancer diagnostics.