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Updated: Jul 10, 2026

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Published on: April 17, 2021
Effects of testosterone on cytokines and left ventricular remodeling following heart failure
Yan-Zhou Zhang1, Xiao-Wen Xing, Ben He
1Department of Cardiology, Renji Hospital, Medical School of Shanghai Jiaotong University, Guangzhou, China.
Aims:
To investigate the effects of testosterone treatment on cytokines, ventricular remodeling in rats with heart failure.
Materials And Methods:
Sprague-Dawley male rats with heart failure were divided into testosterone (n = 22) and placebo (n = 22) group. Pseudo surgery was performed on a third group of 15 male rats as control.
Results:
Compared with the placebo group, the testosterone group had a greater LVEF (P <0.05), a higher serum IL-10 level (P <0.05) and a lower serum TNF-alpha level (P<0.05). The expression of TNF-alpha mRNA, MMP-9 mRNA and the myocardial hydroxyproline contents in the testosterone group were also lower than in the placebo group (P<0.05). The mortality rate in the testosterone and placebo group was 31.8% and 68.2%, respectively (P <0.05).
Conclusion:
Serum testosterone levels were decreased significantly in male rats with heart failure. Testosterone treatment diminishes the imbalance between interleukin-10 and TNF-alpha, suppresses ventricular remodeling and improves cardiac function.
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