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Sex differences in myocardial infarction events between patients with and without conventional risk factors: the

Mohammad Reza Mahmoodi1, Ali Reza Abadi, Seyed Masud Kimiagar

  • 1Nutrition Department, School of Health, Kerman University of Medical Sciences, Kerman, Iran. mahmoodimr@yahoo.com

The American Heart Hospital Journal
|November 6, 2007
PubMed

Insights

This study found that traditional risk factors like hyperlipidemia, diabetes mellitus, and hypertension significantly impact myocardial infarction (MI) risk, particularly in women. Women with all three factors faced a substantially higher risk of MI.

Area of Science:

  • Cardiology
  • Hematology
  • Metabolic Disorders

Background:

  • Myocardial infarction (MI) remains a leading cause of mortality globally.
  • Understanding traditional risk factors and hematologic-metabolic profiles is crucial for MI prevention.
  • Sex-based differences in cardiovascular disease risk factors require further investigation.

Purpose of the Study:

  • To profile traditional risk factors and hematologic-metabolic parameters in myocardial infarction (MI) patients.
  • To analyze sex-specific differences in these parameters and their association with MI risk.
  • To determine the relative risk associated with combinations of key risk factors.

Main Methods:

  • Retrospective analysis of 594 MI patients (1994-2005).
  • Comparison of hematologic-metabolic parameters (hemoglobin, hematocrit, cholesterol, glucose) between sexes.
  • Evaluation of traditional risk factors: hyperlipidemia (HLP), diabetes mellitus (DM), and hypertension (HTN).

Main Results:

  • Significant sex-based differences observed in age, hemoglobin, hematocrit, and fasting blood glucose.
  • Men with hyperlipidemia and family history showed different hemoglobin and hematocrit levels.
  • Relative risks for HLP, DM, and HTN were higher in women, with a 6.16-fold increased risk for the 3-factor combination.

Conclusions:

  • Hyperlipidemia, diabetes mellitus, and hypertension are critical contributors to MI occurrence.
  • Women exhibit a significantly elevated relative risk for MI associated with these traditional risk factors.
  • Targeted risk factor management, especially in women, is essential for MI prevention.

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