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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
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Respiratory Syncytial Virus Disease01:29

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...
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Cell-mediated Immune Responses

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Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...

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Related Experiment Video

Updated: Jul 10, 2026

Automated Cell Enrichment of Cytomegalovirus-specific T cells for Clinical Applications using the Cytokine-capture System
10:24

Automated Cell Enrichment of Cytomegalovirus-specific T cells for Clinical Applications using the Cytokine-capture System

Published on: October 5, 2015

Adoptive cellular immunotherapy for viral diseases.

Y Fujita1, C M Rooney, H E Heslop

  • 1Baylor College of Medicine, The Methodist Hospital and Texas Children's Hospital, Houston, TX, USA.

Bone Marrow Transplantation
|November 6, 2007
PubMed
Summary

Viral infections pose risks after pediatric stem cell transplants. Donor T cells can restore immunity against viruses like cytomegalovirus, Epstein-Barr virus, and adenovirus, aiding prevention and treatment.

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Automated Cell Enrichment of Cytomegalovirus-specific T cells for Clinical Applications using the Cytokine-capture System
10:24

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Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant
08:52

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant

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Expanding Cytotoxic T Lymphocytes from Umbilical Cord Blood that Target Cytomegalovirus, Epstein-Barr Virus, and Adenovirus
11:18

Expanding Cytotoxic T Lymphocytes from Umbilical Cord Blood that Target Cytomegalovirus, Epstein-Barr Virus, and Adenovirus

Published on: May 7, 2012

Area of Science:

  • Immunology
  • Hematology
  • Transplantation

Background:

  • Viral infections are a significant cause of illness and death in children undergoing hematopoietic stem cell transplantation (HSCT).
  • Re-establishing a robust immune system is critical for patient survival post-HSCT.
  • Antiviral immunity is often compromised after HSCT, leaving recipients vulnerable to opportunistic infections.

Purpose of the Study:

  • To investigate the potential of adoptive transfer of virus-specific T cells for managing viral infections post-pediatric HSCT.
  • To evaluate the efficacy of donor-derived T cells in preventing and treating specific viral infections.
  • To explore strategies for broadening the scope of viral protection safely and efficiently.

Main Methods:

  • Adoptive transfer of donor-derived virus-specific T cells.
  • Monitoring of viral loads and clinical outcomes in pediatric HSCT recipients.
  • Assessment of immune reconstitution and antiviral responses.

Main Results:

  • Donor-derived virus-specific T cells can reconstitute antiviral immunity in HSCT recipients.
  • This approach is effective in both preventing and treating cytomegalovirus, Epstein-Barr virus, and adenovirus infections.
  • The therapy shows promise for restoring immune defense against specific viral pathogens.

Conclusions:

  • Adoptive T cell therapy is a viable strategy to combat viral infections after pediatric HSCT.
  • Further research is ongoing to expand protection against a wider array of viruses.
  • The goal is to provide rapid, safe, and effective antiviral immunity for transplant recipients.