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Related Experiment Video

Updated: Jul 10, 2026

A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder

A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder

Published on: June 18, 2018

Cocaine and sleep: early abstinence.

Peter T Morgan¹, Robert T Malison

¹Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA. peter.morgan@yale.edu

Thescientificworldjournal

|November 6, 2007

Summary

Cocaine addiction severely disrupts sleep, with objective measures showing worsening sleep during early abstinence. Subjective reports, however, improve, contrasting with declining cognitive performance.

Area of Science:

Neuroscience
Sleep Medicine
Addiction Research

Background:

Compulsive cocaine use leads to significant sleep disturbances.
Chronic cocaine use results in deteriorating sleep quality during the initial weeks of abstinence.
This deterioration shows no signs of recovery within the observed period.

Purpose of the Study:

To review the literature on cocaine use and its impact on sleep.
To explore the discrepancy between objective sleep measures and subjective reports during abstinence.
To discuss the clinical relevance of sleep disturbances in cocaine use disorder (CUD) and its treatment.

Main Methods:

Literature review of studies investigating cocaine use and sleep patterns.
Analysis of objective sleep data (e.g., polysomnography) in abstinent individuals.

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Examination of subjective sleep quality reports and cognitive performance assessments.

Main Results:

Objective sleep quality significantly declines in the first 3 weeks of cocaine abstinence.
Subjective reports of sleep quality paradoxically improve during abstinence.
Sleep-related cognitive performance deteriorates despite improved subjective sleep reports.

Conclusions:

A significant dissociation exists between objective and subjective sleep measures in individuals with cocaine use disorder during abstinence.
The underlying mechanisms driving this dissociation require further investigation.
Understanding this sleep disturbance is crucial for developing effective treatments for cocaine addiction.